diet exercise diabetes 2 Irisin From Wikipedia, the free encyclopedia PGC1-alpha Irisin is a hormone being researched by scientists at the Harvard M

Irisin
From Wikipedia, the free encyclopedia


PGC1-alpha
Irisin is a hormone being researched by scientists at the Harvard Medical School which can replicate some of the positive effects of exercise and diet.[1]
Contents [hide]
1 Research Team
2 Mechanism
3 Effect on Fat
4 Effect on Diabetes
5 Effect on Weight Loss
6 See also
7 External links
8 References
[edit]Research Team

The research was done at Harvard Medical School by Dr. Bruce Spiegelman PhD, who is a cell biologist at the Dana Farber Cancer Institute and a professor at Harvard Medical School. The research has been licensed to Ember Therapeutics Inc., a company co-founded by Spiegelman.[2]
[edit]Mechanism

Exercise causes production of the chemical PGC1-alpha in muscles. The presence of that chemical causes production of the protein Fndc5, which the researchers named Irisin, after the Greek goddess Iris.[3][4]
[edit]Effect on Fat

The scientists have reported that the hormone helps convert 'white fat' to 'brown fat'. Brown fat has typically been found only in small amounts in adults, but is common in babies and children. Brown fat burns calories.[5][6]
[edit]Effect on Diabetes

Dr. Spiegelman injected irisin into obese, pre-diabetic laboratory mice and the animals displayed improved glucose intolerance when fed a high-fat diet while maintaining a no exercise regime.[7]
[edit]Effect on Weight Loss

After 10 days of treatment with the irisin injections, the mice lost a small amount of weight.
[edit]See also

GW 501516
[edit]External links

Research Study published in Nature
[edit]References

^ "New pill that 'helps you to stay fit without exercise'". Telegraph. Retrieved January 12, 2012.
^ "Study finds exercise-related hormone may help obesity". Utah Daily Herald. Retrieved January 12, 2012.
^ "Exercise Hormone May Fight Obesity and Diabetes". New York Times. Retrieved January 12, 2012.
^ Boström, P.; Wu, J.; Jedrychowski, M. P.; Korde, A.; Ye, L.; Lo, J. C.; Rasbach, K. A.; Boström, E. A. et al. (2012). "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis". Nature. doi:10.1038/nature10777. edit
^ "Newly Discovered Hormone Boosts Effects of Exercise, Could Help Fend Off Diabetes". Scientific American. Retrieved January 12, 2012.
^ "Brown Fat: A Fat That Helps You Lose Weight?". Time. Retrieved January 12, 2012.
^ "Newly Discovered Irisin Hormone Could Be Developed as Treatment for Obesity, Diabetes". Emaxhealth.com. Retrieved January 12, 2012.

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This page was last modified on 15 January 2012